Demonstration and inspection (via Skype or
in person) can be arranged. Clickherefor more information.
Presster is more than a
Compaction Simulator. It is a Linear Mechanical Replicator of
any Rotary Tablet Press. It will allow you to
to easily test any formulation under high speed manufacturing
conditions, one tablet at a time, using a very small amount of powder. The system has a full spectrum of scientific
tools necessary to optimize and scale-up tablet formulations:
compaction and ejection profiles, elastic recovery, Heckel
analysis, take-off forces to study sticking, adhesion,
capping and lamination. All reports and graphs
are in MS Excel format.
It is a tablet press replicator
designed to match compression force and dwell time of any press.
It is a compaction
simulator designed to mimic a punch
displacement profile of any press.
It is a high-speed single station tablet press with
standard tooling.
It is a powerhouse computer for compressibility profiles,
Heckel plots, lubricant studies, etc.
The Presster™ Features are:
Standard IPT B tooling, upper and
lower compression rolls, ejection cam, take-off bar, variable speed motor
controller, tablet weight and thickness adjustments and overload protection mechanism.
A choice of interchangeable
compression rolls (and, optionally, precompression rolls) to mimic the loading pattern of any rotary tablet press, with easy
changeover mechanisms.
Instrumentation to measure
precompression, compression, ejection, take-off and die wall forces, punch displacement,
and press speed.
Manual or automatic (gravity
force) feed shoe mechanism.
Computerized adjustment of depth
of fill (tablet weight), lower wheel position (tablet thickness), and press speed (in
terms of dwell time).
Pentium computer and color
printer for scientific reports and plots.
State-of-the-art software with a
comprehensive database of parameters for various tablet presses, to match dwell times and
compression profiles.
Comprehensive user manual,
technical documentation, and validation protocol.
The Presster™ Functionality:
Under computer control the Presster™
will
Make tablets with up to 50 kN
compression force at a user specified speed (dwell time).
Display
compression waveform and peak force, peak offset time, decompression time,
dwell time, contact time, and other measurements.
Measure punch displacement,
calculate tablet volume, elastic recovery, work of compaction, and display
Heckel or stress vs. strain plots.
Allow
input of tablet weight in g or mg, tablet thickness and diameter in mm or
inches, and hardness in kP, SCU, or N.
Display an array of scientific
plots and reports that are widely used in formulation development.
Display compressibility profile
where each point corresponds to compression and hardness for each tablet made,
or sample average. This plot can be converted into tensile strength vs.
compression pressure.
The Presster™ Software:
Mouse / menu driven under Windows
Produces reports and plots in the Excel (raw waveforms, analytical graphs,
and
statistics for all tablets made).
Provides the means for comparing different
compressibility profiles or Heckel plots, e.g. superimposing the current profile with
previously collected graphs.
Has a comprehensive context sensitive on-line help.
Prints on demand any screen graph, report or display on the
color printer.
Full control of the Presster hardware
Presster™ Standard Specifications:
Maximum compression force
50 kN
Maximum
precompression force
10 kN
Maximum depth of fill
17.4 mm
Maximum tablet thickness
8 mm
Tooling
TSM/Euro, B
type, any shape and size (D type is optional)
A variety of compression and precompression rolls to the
exact diameters of the specified production presses.
Additional functionality: Precompression event and force
measurement, variable ejection cam angle.
Integrated 4-way tablet tester (weight, thickness,
diameter, and hardness measurements).
Validation Protocol, including IQ / PQ testing and all
relevant documentation.
IPT D Type or any custom type tooling
Dwell Time Calculations for Scale-Up of Tableting Process
To compute a dwell time for any press,
we use the following formula:
DT (msec) =
PHF · NP
·3,600,000
π · PCD · TPH
Where PHF = 12.7 mm (Punch Head
Flat of the TSM-B )
NP = Number of Stations
π
= 3.141
PCD = Pitch Circle Diameter of the turret
TPH = press speed in terms of Tablets
Per Hour
The following graph represents
the dwell time ranges for different R&D and production presses. The
fastest presses, such as Fette, can achieve dwell
times of about 5 ms. All high speed production presses are normally run at
dwell times well under 10 ms. This is well within the
range of a Manesty Betapress or MCC Presster™, but other
research presses such as Korsch XL100 or Riva Piccola do not compare.
Presster™ can reach the dwell time of 5.8 ms (as calculated on
the basis of 12.7 mm PHF).
To avoid any misunderstanding regarding the
dwell time definition, it is best to compare ranges of press speeds in terms of
linear speed in horizontal plane. The following graph makes such comparison
clear. Note that typical production ranges of linear speed are between 1500 to
2000 mm/s.
It is the linear speed (rather than the changes in
dwell time at the same speed, e.g. by changing tooling geometry) that has a
demonstrated effect on compaction process for strain-rate sensitive products.
Presster™
Options:
